Table 1. Prognostic values of SLC genes expression in PDAC.
| Gene expression | Events/total (n=112) | MST (days) | Crude HR (95% CI) | Crude P value | Adjusted HR (95% CI) | Adjusted P valuea |
|---|---|---|---|---|---|---|
| SLC19A3 | ||||||
| Low | 39/56 | 449 | 1 | 1 | ||
| High | 30/56 | 756 | 0.460 (0.276–0.766) | 0.003 | 0.447 (0.250–0.800) | 0.007 |
| SLC22A23 | ||||||
| Low | 43/56 | 497 | 1 | 1 | ||
| High | 26/56 | 756 | 0.447 (0.272–0.732) | 0.001 | 0.526 (0.289–0.956) | 0.035 |
| SLC22A4 | ||||||
| Low | 38/56 | 506 | 1 | 1 | ||
| High | 31/56 | 732 | 0.581 (0.357–0.945) | 0.029 | 0.676 (0.397–1.151) | 0.149 |
| SLC25A11 | ||||||
| Low | 38/56 | 554 | 1 | 1 | ||
| High | 31/56 | 681 | 0.598 (0.368–0.971) | 0.038 | 0.647 (0.382–1.096) | 0.105 |
| SLC25A39 | ||||||
| Low | 30/56 | 748 | 1 | 1 | ||
| High | 39/56 | 503 | 1.880 (1.153–3.065) | 0.011 | 1.852 (1.071–3.202) | 0.027 |
| SLC26A10 | ||||||
| Low | 43/56 | 549 | 1 | 1 | ||
| High | 26/56 | 684 | 0.613 (0.375–1.003) | 0.051 | 0.931 (0.528–1.641) | 0.804 |
| SLC35B4 | ||||||
| Low | 37/56 | 504 | 1 | 1 | ||
| High | 32/56 | 714 | 0.582 (0.356–0.953) | 0.031 | 0.707 (0.402–1.244) | 0.229 |
| SLC35E2 | ||||||
| Low | 42/56 | 534 | 1 | 1 | ||
| High | 27/56 | 754 | 0.584 (0.356–0.955) | 0.032 | 0.674 (0.401–1.133) | 0.137 |
| SLC39A11 | ||||||
| Low | 32/56 | 705 | 1 | 1 | ||
| High | 37/56 | 538 | 1.699 (1.046–2.761) | 0.032 | 1.749 (1.017–3.009) | 0.043 |
| SLC46A2 | ||||||
| Low | 37/56 | 524 | 1 | 1 | ||
| High | 32/56 | 727 | 0.549 (0.336–0.895) | 0.016 | 0.783 (0.454–1.350) | 0.378 |
| SLC47A1 | ||||||
| Low | 39/56 | 459 | 1 | 1 | ||
| High | 30/56 | 769 | 0.409 (0.249–0.670) | <0.001 | 0.504 (0.278–0.913) | 0.024 |
| SLC52A1 | ||||||
| Low | 40/56 | 544 | 1 | 1 | ||
| High | 29/56 | 688 | 0.611 (0.376–0.993) | 0.047 | 0.774 (0.430–1.289) | 0.292 |
Italic P values indicate statistically significant. a, adjusted for histologic grade, radiation therapy, radical resection, and targeted molecular therapy. SLC, solute carrier; MST, median survival time; OS, overall survival; PDAC, pancreatic ductal adenocarcinoma; HR, hazard ratio; CI, confidence interval.