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. 2022 Jan;10(2):109. doi: 10.21037/atm-21-4222

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Genes regulated by HIF-1α and their effects on cancer progression. HIF-1α, hypoxia-inducible factor-1 alpha; EPO, erythropoietin; TGF-β3, transforming growth factor β3; VEGF, vascular endothelial growth factor; NOS, nitric oxide synthase; TGF-α, transforming growth factor α; C-MYC, myelocytomatosis virus oncogene cellular homolog; iNOS, inducible nitric oxide synthase; HO-1, heme oxygenase-1; ID2, DNA-binding protein inhibitor; IGF-2, insulin-like growth factor 2; IGF-BP 1/2/3, IGF-binding protein 1/2/3; ADM, adrenomedullin; FN1, fibronectin 1; LOXL2, lysyl oxidase-like 2; uPAR, urokinase plasminogen activator receptor; FLT-1, VEGF receptor FLT-1; TIE-2, tyrosine kinase with immunoglobulin and EGF-like domains 2; PAI-1, plasminogen activator inhibitor 1; EGF, epidermal growth factor; TIMP-1, tissue inhibitor of metalloprotease-1; ANGPT, angiopoietin; LEP, leptin; LRP1, LDL-receptor-related protein 1; Bcl-2, B-cell lymphoma 2; NIP3, nonimprinted polymer 3.