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. 2022 Jan;10(2):109. doi: 10.21037/atm-21-4222

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Metabolism-related genes targeted by HIF-1α. Metabolism mainly includes glycolysis metabolism, nucleotide metabolism, iron metabolism, and collagen metabolism. HIF-1α,hypoxia-inducible factor-1 alpha; AK3, adenylate kinase 3; GLUT1/3, glucose transporter 1 and 3; PFK, phosphofructokinase; PFK2, 6-phosphofructo-2-kinase; PFKL, phosphofructokinase L; POK1, phragmoplast orienting kinesin 1; FBPase, fructose-1,6-bisphosphatase; PGK1, phosphoglycerate kinase 1; PDK1, pyruvate dehydrogenase kinase 1; ALDOA, fructose biphosphate aldolase A; TPI, triosephosphate isomerase; GAPDH, glyceraldehyde-3-P-dehydrogenase; HK1/2, hexokinase 1 and 2; LDHA, lactate dehydrogenase A; PKM, pyruvate kinase muscle isozymes; ALDA, aldolase A; ALDC, aldolase C; ENO1, enolase 1; Cp, ceruloplasmin; TF, transferrin; TFRC, transferrin receptor; PHα(I), prolyl-4-hydroxylase α(I).