Table 1. Function and potential mechanism of HIF-1α in HCC.
| Function | Related genes and pathways | References |
|---|---|---|
| Migration | IL-8/NF-κB axis | (125) |
| Invasion | HIF-1α/RIT1 axis | (125) |
| Metastasis | HIF-1α/IL-8/Akt axis | (126) |
| Angiogenesis | Upregulates the expression of LOXL2 and BCLAF1 | (127,128) |
| Glycolysis | HIF-1α/PPAR-γ/PKM2 axis | (129) |
| EMT | PTEN/p-AKT/HIF-1α signaling pathway | (130) |
| Lipid metabolism | FABP5/HIF-1α axis | (131) |
| Drug resistance | miR-183-IDH2/SOCS6-HIF-1α feedback loop | (132) |
| PFKFB3/HIF-1α feedback loop | (133) |
HIF-1α, hypoxia-inducible factor-1 alpha; HCC, hepatocellular carcinoma; EMT, epithelial to mesenchymal transition.