Skip to main content
. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem. 2020 Nov 6;29:115836. doi: 10.1016/j.bmc.2020.115836

Scheme 2. Reagents and Conditions:

Scheme 2.

(a) dry THF, NaH, 0 °C, 30′, then cC3H5-COCl, r.t., o/n; (b) HCl 37%, SnCl2·2H2O, r.t., 30′; (c) Et3N, DMF/1,4-Dioxane, R-COCl, 50 °C, 4 h; (d) CH3COCl, Et3N, anhydrous CH2Cl2, 0 °C, 2 h, then r.t., 2 h.