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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem. 2020 Nov 6;29:115836. doi: 10.1016/j.bmc.2020.115836

Scheme 5. Reagents and Conditions:

Scheme 5.

(a) NCS, CCl4, (PhCOO)2, reflux, 12 h; b) NaOH 6 N, reflux, 2 h; c) CCl3CN, PPh3, dry DCM, r.t., 4 h then appropriate amine (m-anisidine or 3-methoxybenzylamine), Et3N, r.t., 12 h.