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BOILED-Egg plot. Points located in the BOILED-Egg’s yellow are the compounds predicted to permeate the BBB passively, differently the ones in the white are the molecules predicted to be only passively absorbed by the gastrointestinal tract. Blue dots indicate molecules expected to be refluxed from the central nervous system (CNS) by the P-glycoprotein, whereas the red ones are not transported by the P-glycoprotein.
