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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem. 2020 Nov 6;29:115836. doi: 10.1016/j.bmc.2020.115836

Scheme 1. Reagents and Conditions:

Scheme 1.

(a) for 2a,b,l-o,r-t: R-COCl, Et3N, anhydrous CH2Cl2, 0 °C, 2 h, then r.t., 2 h; for 2c: Benzyl bromide, anhydrous CH3CN, K2CO3, reflux, 4 h; for 2d: Ph-COOH, dry THF, HOBt, Et3N, DCC, 0 °C, 30′, then r.t., 48 h; for 2e-i,p,q: dry THF, NaH, 0 °C, 30′, then R-COCl, r.t., o/n.