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. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Bioorg Med Chem. 2020 Nov 6;29:115836. doi: 10.1016/j.bmc.2020.115836

Table 3.

HNE inhibitory activity of compounds 22a-h.

graphic file with name nihms-1775426-t0003.jpg
Compound R R2 R3 IC50 (μM)a
22a m-(OCH3)-Ph CH3 H N.A.b
22b m-(OCH3)-Ph t-Bu H N.A.b
22c m-(OCH3)-Ph t-Bu Cl N.A.b
22d m-(OCH3)-Bn CH3 H N.A.b
22e m-(OCH3)-Bn t-Bu H N.A.b
22f m-(OCH3)-Bn t-Bu Cl N.A.b
22 g m-(OCH3)-Ph – – N.A.b
22 h m-(OCH3)-Bn – – N.A.b
Sivelestat 0.050 ± 0.020
a

IC50 values are presented as the mean ± SD of three independent experiments.

b

N.A.: no inhibitory activity was found at the highest concentration of compound tested (50 μM).