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a Illustration of genome sequence data pre-processing and BFE change predictions. b Comparison of experimental CT-P59 IC50 fold change (reduction)35 and predicted BFE changes induced by mutations L452R and T478K. c Comparison of predicted BFE changes and relative luciferase units25 for pseudovirus infection changes of ACE2 and S protein complex induced by mutations L452R and N501Y.
