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. Author manuscript; available in PMC: 2022 Aug 20.
Published in final edited form as: Gene Ther. 2021 Jul 6;29(7-8):418–424. doi: 10.1038/s41434-021-00275-5

Fig. 5. rAAV9 effectively and safely transduces normal prostate and PCa cells in vivo.

Fig. 5

A rAAV9-EGFP was injected into two lobes of the AP and two lobes of the DLP for 4 weeks. After cyrosectioning, EGFP fluorescence was observed using a fluorescence microscope. The AAV GC number in the prostate was detected using ddPCR. B Xenografts of TRAMP-C2 cells in C57 mice were intratumorally injected with rAAV9-EGFP for 7 days, and EGFP fluorescence was observed using a fluorescence microscope after cryosectioning at low and high magnification. The AAV GC number in tumor tissue was detected using ddPCR. C The ALT and AST levels were detected using sera from mice injected with rAAV9-EGFP. ALT alanine aminotransferase, AST aspartate aminotransferase.