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. 2022 Feb 8;17(9):2072–2078. doi: 10.4103/1673-5374.335168

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(D-Ser2) Oxm increases the theta power in the hippocampal CA1 of 9-month-old 3xTg mice.

(A) The peak value of the theta rhythm in the CA1 region was recorded before and after conditioned stimulation during the testing session. In WT + saline mice, the frequency of the theta rhythm in the CS stage was higher than that in the pre-CS stage. (B) Peak power of theta rhythm in CA1 region before and after conditioned stimulation during the testing session. (C) The peak frequency of the theta rhythm in the CA1 region before and after conditioned stimulation during the testing session. All values are shown as mean ± SEM (n = 10). ***P < 0.001 (one-way analysis of variance followed by post hoc Tukey's multiple comparison tests). 3xTg: APP/PS1/tau; CS: conditioned stimulus; Oxm: oxyntomodulin; WT: wild-type.