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. 2022 Feb 8;17(9):1991–1997. doi: 10.4103/1673-5374.335162

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Copyright: © Neural Regeneration Research

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Effect of SGB on infarct volume and eye changes in ischemic stroke diabetic rats.

(A) Eye changes before and after SGB. After SGB, rats had ptosis, and eye fissure reduction. (B) Representative images of 2,3,5-triphenyl tetrazolium chloride staining. Significant hemispheric ischemia (white) was present 48 hours after MCAO, whereas it was significantly improved in the MCAO + SGB daytime group and MCAO + SGB night group. (C) Quantitative analysis of hemispheric infarct ratio. (D) Quantitative analysis of brain water content. The data are presented as the mean ± SD (n = 6). *P < 0.05, vs. Sham group; #P < 0.05, vs. MCAO + SGB daytime group; †P < 0.05, vs. MCAO + SGB + LPS group (one-way analysis of variance followed by the Student-Newman-Keuls test). LPS: Lipopolysaccharide, a Toll-like receptor 4 agonist; MCAO: middle cerebral artery occlusion; SGB: stellate ganglion block; TAK-242 (Resatorvid): a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling.