Additional Table 2.
Selected publications on the reprogramming of non-human primates (NHP) cells into induced pluripotent stem cells (iPSC)
| Reference | Somatic cell source (isolated from)* | Reprogramming | Reprogramming ^ Maintenance (Feeders/Feeder-free) | Directed differentiation*** | Species**** | |
|---|---|---|---|---|---|---|
|
| ||||||
| Method | Factors used** | |||||
| Liu et al., 2008 | Fibroblasts (Adult ear skin) | Retrovirus | OSKC / Macaque | Feeders/Feeders | Rhesus monkey | |
| Wu etal., 2010 | Fibroblasts (Newborn skin) | Retrovirus | OSKC/Human | Feeders/Feeder-free | Marmoset | |
| Tomioka et al., 2010 | Liver cells (Fetal) | Retrovirus | OSKCNL/Human | Feeders/Feeders | Neuron-like cells | Marmoset |
| Chan etal., 2010 | Fibroblasts (Fetal skin) | Lentivirus | OSK/Macaque | Feeders/Feeders | Neuron-like cells | Rhesus monkey |
| Zhong et al., 2011 | Fibroblasts (Oral mucosa) | Retrovirus | OSKC/Human | Feeders/Feeder-free | Neuron-, cardiomyocyte-, hepatocyte- and hematopoietic- cell-like cells | Pig-tailed macaque |
| Friedrich Ben-Nun et al., 2011 | Fibroblasts (Adult skin) | Retrovirus | OSKC/Human | Feeders/Feeders | Drill | |
| Okahara-Narita et al., 2012 | Fibroblasts (Adult and fetal skin) | Retrovirus | OSKC/Human | Feeders/Feeders | Cynomolgus monkey | |
| Wunderlich et al., 2012 | Fibroblasts (Adult skin) | Simian immunodeficiency virus (SIV)-based vector | OSKC/Human | Feeders/Feeders | Cardiomyocyte-like cells | Cynomolgus monkey |
| Wiedemann et al., 2012 | Mesenchymal stem cells (Adult/ Bone marrow) | Excisable lentiviral vector | OSKC/Human | Feeder-free/Feeders | Neuron-like cells, megakaryocytes, adipocytes, chondrocytes, and osteogenic cells | Marmoset |
| Shimozawa et al., 2013 | Skin and liver cells (Newborn and fetal) | Retrovirus | OSKC / Macaque | Feeders/Feeders | Cynomolgus monkey | |
| Marchetto etal., 2013 | Fibroblasts (Adult skin) | Retrovirus | OSKC/Human | Feeders/Feeder-free | Chimpanzee and bonobo | |
| Morizane et al., 2013 | Fibroblasts (Adult oral mucosa) and peripheral blood mononuclear cells (Adult blood) | Retrovirus / Episomal vectors | OSKL plus L-MYC/ Human | Feeders/Feeders | DA neuron-like cells | Cynomolgus monkey |
| Navara etal., 2013 | Fibroblasts (Fetal skin) | Retrovirus | OSKC/Human | Feeders/Feeders | Baboon | |
| Emborg et al., 2013 | Fibroblasts (Adult skin and subcutaneous tissue) | Retrovirus | OSKC/Human | Feeders/Feeders | DA neuron-like cells | Rhesus monkey |
| Fang et al., 2014 | Fibroblasts (Adult ear skin) | Retrovirus | OK/Human | Feeders/Feeders | Rhesus monkey | |
| Wunderlich et al., 2014 | Endothelial cells or Fibroblasts | Lentivirus | OSKC/OSNL / Human | Feeders/Feeders | Cynomolgus monkey, Gorilla, and Bonobo | |
| Debowski et al., 2015 | Fibroblasts (Newborn skin) | PiggyBac | OSKCNL / Marmoset | Feeders/Feeders | Marmoset | |
| Wang et al., 2015 | Mesenchymal stem cells (Adult/ Bone marrow) | Retrovirus | OSKC/Human | Feeders/Feeders | DA neuron-like cells | Cynomolgus monkey |
| Coppiello et al., 2017 | Fibroblasts (Adult skin) | Sendai virus | OSKC/Human | Feeders/Feeders | Cynomolgus monkey | |
| Vermilyea et al., 2017 | Fibroblasts (Adult skin and subcutaneous tissue) | Episomal vectors | OSKCNL/Human | Feeder-free/Feeder-free | DA neuron-like cells | Marmoset |
| Navara etal., 2018 | Peripheral blood mononuclear cells (Adult blood) | Sendai virus | OSKC/Human | Feeders/Feeders (Feeder conditioned medium) | Baboon | |
| Yang etal., 2018 | Fibroblasts (Adult skin) | Episomal vectors | OSKL plus L-MYC /Human | Feeders/Feeders | DA neuron-like cells | Marmoset |
| Watanabe etal., 2019 | Liver cells (Newborn liver) and fibroblasts (Fetal, newborn and adult skin) | mRNAs | OSKMNL/Human | Feeders/Feeder-free (Feeder conditioned medium) | Marmoset and cynomolgus monkey | |
| Nakajima etal., 2019 | Fibroblasts (Fetal skin) | mRNAs | OSKCNL/Human | Feeder-free / Feeders | Marmoset | |
| Rodriguez-Polo et al., 2019 | Fibroblasts (Adult skin) | PiggyBac | OSKCNL / Marmoset | Feeders/Feeder-free | Baboon | |
| Aron Badin etal., 2019 | Peripheral blood mononuclear cells (Adult blood) | Sendai virus | OSKC/Human | Feeders/Feeders | Striatal neuron precursors | Cynomolgus monkey |
| Stauske et al., 2020 | Fibroblasts (Adult and newborn skin) | Episomal vectors | OSKL plus L-MYC / Human | Feeder-free/Feeder-free | Cardiomyocyte-like cells | Rhesus monkey and baboon |
| Petkov et al., 2020 | Fibroblasts (Fetal skin) | VEE-mRNAs | OSKC /Human | Feeder-free/Feeder-free | Neuron- and cardiomyocyte-like cells | Marmoset |
| Geuder et al., 2021 | Urinary cells (Urine) | Episomal vectors / Sendai virus | OSKC /Human | Feeder-free/Feeder-free | Neural stem cells | Gorilla and orangutan |
| Ishigaki et al., 2021 | Fibroblasts (Adult skin) Peripheral blood T cells (Adult blood) | Lentivirus vectors / Sendai virus | OSKC /Human | Feeders/Feeder-free | Mesenchymal Stem Cells | Rhesus monkey |
| Yoshimatsu et al., 2021 | Fibroblasts (Fetal and adult skin) | Episomal vectors | OSKL plus L-MYC GLIS1, and KDM4D /Human | Feeders/Feeders | Primordial germ cell-like cells | Marmoset |
| Rodriguez-Polo et al., 2021 | Fibroblasts (Adult skin) | PiggyBac | OSKCNL / Marmoset | Feeders/Feeder-free | Rhesus monkey | |
(*) Somatic cell source includes the information about the somatic cells used for reprogramming, including the tissue they were extracted from and the developmental stage of the NHP. (**) Pluripotency factors used for reprogramming. OCT4 (O), SOX2 (S), KLF4 (K), and c-MYC (C), NANOG (N) and LIN28 (L). Some studies include additional non-coding factors to increase the efficiency ofreprogramming, e.g., miRNAs, which have not been included in the table. (***) Directed differentiation of the generated NHP-iPSC towards a specific cell type. DA neuron-like