FIGURE 7.

Arsenic trioxide exposure causes cardiac hypertrophy in mice that is reduced upon Honokiol pretreatment. Representative images of histological analysis of cardiac interstitial fibrosis, picrosirius red staining shows that the cardiac fibrosis increases in arsenic‐treated mice heart tissue compared to control after 4 weeks of treatment. The fibrosis level is reduced in case of Honokiol pretreatment (A). Statistical results for the fibrotic area (n > 40 fields per group) (B), quantification results for mRNA levels of the fibrotic marker genes (collagen I, collagen III) in the indicated groups (C). The data are expressed as means ± SD, n = 6–8, *p < .05 versus vehicle in sham; ^# p < .05 versus vehicle in ATO‐exposed mice