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. 2022 Feb 16;22:85. doi: 10.1186/s12935-022-02512-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overexpression of CBS inhibits HT-29 cell proliferation, clone formation and migration. A Overexpression of CBS protein in HT-29 cells after lentivirus infection (*p < 0.05). B H₂S fluorescent probe visualizing the intracellular levels of H₂S in HT-29 control and CBS-overexpressing cells. Scale bar, 20 μm. C The proliferation of HT-29 control and CBS-overexpressing cells assessed by CCK-8 assay (*p < 0.05, **p < 0.01). D, E Colony-formation assay of HT-29 control and CBS-overexpressing cells (**p < 0.01). F, G Sphere formation assay of HT-29 control and CBS-overexpressing cells (**p < 0.01). Scale bar, 50 μm. H, I Migration capacity determined by transwell assay in HT-29 control and CBS-overexpressing cells (***p < 0.001). Scale bar, 100 μm