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. 2022 Feb 16;22:85. doi: 10.1186/s12935-022-02512-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Exogenous H₂S inhibits CRC cell proliferation and migration. A GYY4137 increases the intracellular levels of H₂S in HT-29 cells visualized by H₂S fluorescent probe. Scale bar, 20 μm. B GYY4137 inhibits the proliferation of HT-29 and HCT-116 cells assessed by CKK-8 assay (*p < 0.05, ***p < 0.001). C Proliferation capacity remains unimpaired after 18-h of GYY4137 treatment in HT-29 and HCT-116 cells. D, E Migration capacity determined by 18-h transwell assay in HT-29 and HCT-116 cells treated with GYY4137 (**p < 0.01, ***p < 0.001). Scale bar, 100 μm