Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 16;19:50. doi: 10.1186/s12974-022-02410-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Co-administered l-DOPA is able to block IL-1β production by primary human microglia in response to canonical (a), non-canonical (b), and α-syn-mediated (c) NLRP3 inflammasome activation. 2 experiments, n = 3. d The protective effect of l-DOPA is reversed by the AADC inhibitor carbidopa, indicating that l-DOPA-mediated inhibition of IL-1β production is a result of the conversion of l-DOPA to DA. e DRD1 agonism with SKF82958 completely blocks IL-1β production by canonical NLRP3 inflammasome activation, similar to DA and l-DOPA, while DRD2 agonism with quinpirole has no effect. 2 experiments, n = 3. f DRD1 and DRD2 agonism both partially block IL-1β production induced by α-syn, suggesting a shared role for these receptors in α-syn-mediated NLRP3 inflammasome activation. Representative experiment. ****p < 0.0001 by two-way ANOVA with Bonferroni multiple testing correction. Shapes represent individual experiments