Table 4.

Summary of utility values included in economic evaluations for health states

Lead author	Neonatal HSV infection						Genital herpes
	Neonatal perspective			Maternal perspective
	HSUV	Duration (years)	Probability of health state	HSUV	Duration (years)	Probability of health state	HSUV	Duration (years)	Probability of health state
Baker [17]	No permanent impairment: 1	76.4	0.56
	Mild: 0.82	76.4	0.05	··	··	··	··	··	··
	Moderate: 0.52	76.4	0.08	··	··	··	··	··	··
	Severe: 0.16	20	0.14	··	··	··	··	··	··
	Death: 0	.	0.17	··	··	··	··	··	··
Caviness [18]	Normal: 1	77.8	··	··	··	··	··	··	··
	Mild: 0.82	77.8	Differs according to treatment arm, time and disease state (e.g., 12-month outcome with acyclovir therapy for disseminated disease: Normal: 0.28, Mild: 0.04, Moderate: 0.02, Severe: 0.13, Death: 0.53)	··	··	··	··	··	··
	Moderate: 0.52	77.8		··	··	··	··	··	··
	Severe: 0.16	20		··	··	··	··	··	··
	Death: 0	.		··	··	··	··	··	··
Chatroux [4]	Mild: 0.82	79.3	HSV-1: 0.69; HSV-2: 0.49	Mild: 0.94	54.8	HSV-1: 0.69; HSV-2: 0.49	··	··	··
	Moderate: 0.52	79.3	HSV-1: 0.01; HSV-2: 0.14	Moderate: 0.87	54.8	HSV-1: 0.01; HSV-2: 0.14	··	··	··
	Severe: 0.16	20	HSV-1: 0.02; HSV-2: 0.17	Severe: 0.76	54.8	HSV-1: 0.02; HSV-2: 0.17	··	··	··
	Death: 0	··	HSV-1: 0.28; HSV-2: 0.2	Death: 0.92	54.8	HSV-1: 0.28; HSV-2: 0.2	··	··	··
Little [19]	Normal neonate: 1	77.2	#	Caesarean delivery: 0.99	55.4	If lesions present at delivery: 1; if no lesions present: 0.244	··	··	··
	Moderate: 0.9	62.0	HSV-1: 0.01, HSV-2: 0.14	Having an impaired child: 0.81	55.4	Not reported	··	··	··
	Severe: 0.3	28.7	HSV-1: 0.01, HSV-2: 0.17	Losing a child: 0.92	55.4	Not reported	··	··	··
	Death: 0	··	HSV-1: 0.28, HSV-2: 0.20	··	··	··	··	··	··
Smith [20]	··	··	··	··	··	··	Stigma: 0.95	10	Unclear
	··	··	··	··	··	··	Symptomatic recurrence: 0.90	10
Tuite [16]	Normal/mild: 1	75	Unclear	··	··	··	··	··	··
	Moderate: 0.84	38	Unclear	··	··	··	··	··	··
	Severe: 0.41	38	Unclear	··	··	··	··	··	··
	Death: 0	··	Unclear	··	··	··	··	··	··
Thung [21]	Normal: 1	76	Unclear	··	··	··	··	··	··
	Mild: 1	76	Unclear	··	··	··	··	··	··
	Moderate: 0.5	76	Unclear	··	··	··	··	··	··
	Severe: 0.1	76	Unclear	··	··	··	··	··	··
	Death: 0	.	Unclear	··	··	··	··	··	··

HSUV health-state utility values; HSV Herpes simplex virus; QALY quality-adjusted life years