Skip to main content
. Author manuscript; available in PMC: 2022 Feb 16.
Published in final edited form as: Stat Methods Med Res. 2019 Jun 7;29(4):1167–1180. doi: 10.1177/0962280219852720

Figure 5.

Figure 5.

Simulation results based on five inflammasome gene SNPs (rs3917365, rs3917243, rs3917296, rs3181052, rs55910638) associated with WB CASP1 expression. Assumed SNP-expression effect estimates are 0.160, −0.096, −0.228, −0.109, and −0.161 respectively, with residual standard deviation given by σδ = 1.262. (a) n1 = 175; n2 = 450, (b) n1 = 175; n2 = 650, (c) n1 = 300; n2 = 450, (d) n1 = 175; n2 = 650; SNP-expression effect sizes based on two-times observed estimates.‡

‡In panel (d), effect sizes of all five SNPs are doubled. Genotype data are sampled with replacement from the observed data in the GENE study and GTEx project, preserving within individual links, to achieve corresponding sample sizes.