Table 1.

Ions observed from analysis of lipids standards deposited on a brain tissue section after implantation of 4 monolayers of 8 nm AgNP.

Lipid	Positive		Negative
species	Positive ion Fragment	Cationization
Cer	[Cer-H2O] Ag+	Ag+	ND
GalCer	[Cer-H2O] Ag+	Na+, K+, Ag+	ND
SM	[Cer-H2O] Ag+	ND	(−CH2-H)−
ST	ND	ND	−H
DAG	ND	Na+, K+, Ag+	−H
TAG*	[DAG-H2O] Ag+	Ag+	−H
PA**	ND	(−H+AgK)+	−H
PC	[DAG-H2O] Ag+	K+, Ag+	(−CH2-H)−
PE	[DAG-H2O] Ag+	K+, (−H+NaK)+, (−H+2K)+, (−H+AgK)+	(−H)−, (+AgCl-H)−
PG*	[DAG-H2O] Ag+	(−H+2K)+, (−H+AgK)+	ND
PI	ND	ND	−H
PS	ND	ND	ND
Myristic acid**	ND	Ag+	(−H)−

^*PG and TAG are observed only from standards because their levels in brain tissue are typically below the limit of detection.

^**PA and myristic acid can also be a fragment from other lipids.

ND means not detected.