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. 2022 Feb 15;15:24. doi: 10.1186/s13048-022-00952-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CircCDK17 silencing inhibited tumor development and glycolysis in CC. A The transfection efficiency of si-circCDK17 was determined by qRT-PCR in C-33A and HeLa cells. B and C The effect of circCDK17 knockdown on cell proliferation was illustrated by CCK-8 assay in C-33A and HeLa cells. D and E The impacts of circCDK17 silencing on the migration and invasion of C-33A and HeLa cells were demonstrated by transwell assay. F Flow cytometry analysis was performed to investigate the influence of circCDK17 knockdown on the apoptosis of C-33A and HeLa cells. G Lactate assay kit was employed to the influence of circCDK17 silencing on lactate production in C-33A and HeLa cells. H Glucose assay kit was used to determine the impact of circCDK17 knockdown on glucose uptake in C-33A and HeLa cells. I ATP detection kit was conducted to present the effect of circCDK17 silencing on ATP level in C-33A and HeLa cells. J and K Western blot was employed to illustrate the effects of circCDK17 downregulation on the protein expression levels of GLUT1 and HK2 in C-33A and HeLa cells. *P < 0.05