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. 2022 Mar;28(3):371–389. doi: 10.1261/rna.079025.121

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© 2022 Black and Johnson; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 7. — A proposed pathway for events surrounding the binding and release of Bud23 from 40S precursors. A revised pathway for the incorporation and release of factors is shown. Late assembling Processome factors, including Enp1, Rrp12, Slx9, Bms1, Dhr1, and possibly Nob1 complete the Processome. The transition of the Processome to pre-40S requires the enzymatic activities of Dhr1 and Bms1, which work in concert with the recruitment of Bud23–Trm112. During this transformation, the remaining Processome factors are released and Tsr1 and Ltv1 are recruited. Next, the Rps0-cluster proteins incorporate into the pre-40S and coexist with Bud23 and Trm112 on the pre-40S. Continued maturation of the pre-40S particle allows the release of Rrp12 and Slx9. The binding of Rio2 to the nascent P-site of the pre-40S actively displaces Bud23 and Trm112, and the nascent 40S continues down its biogenesis pathway.