Fig. 8.

Overexpression of ITGA6 mitigates up-regulated miR-92a-mediated effects on the growth of OC cells. A-B ITGA6expression in SKOV3 and A2780 cells was detected by Western blot; C viability of SKOV3 and A2780 cells was detected by CCK-8 assay; D expression of EMT-related proteins in OC cells was measured by RT-qPCR; E colony formation ability of SKOV3 and A2780 cells was detected by colony formation assay; F Transwell assay was employed to determine the invasion ability of SKOV3 and A2780 cells; G migration ability of SKOV3 and A2780 cells was evaluated by scratch test; H apoptosis rates of SKOV3 and A2780 cells were measured by flow cytometry; + P < 0.05 vs the miR-92a mimic + oe-NC group; the data were expressed as mean ± standard deviation and the t-test was performed for comparisons between two groups