Table 2.

Associations between the combined effects of high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) levels with the risk of dementia

Combined effect of hs-CRP and HbA1c	Numbers	Event	PYs	Crude model		Adjusted model †
				HR (95% CI)	P value *	HR (95% CI)	P value *
High levels of both hs-CRP and HbA1c	756	32	5850	5.69 (3.08 ~ 10.51)	< 0.001	2.36 (1.20 ~ 4.62)	0.012
High level of only hs-CRP	682	19	5408	3.66 (1.86 ~ 7.19)	< 0.001	2.58 (1.29 ~ 5.17)	0.007
High level of only HbA1c	772	40	6082	6.85 (3.79 ~ 12.40)	< 0.001	2.52 (1.34 ~ 4.74)	0.004
Non-high levels in both	1903	15	15,586	1.00		1.00

PYs person-years, HR hazard ratio, CI confidence interval

^*Analyzed using Cox proportional hazards regression analyses

^†Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, triglycerides, body mass index, exercise status, smoking status, alcohol consumption, heart diseases, stroke, and chronic infection or inflammation

^‡Cutoff points for a high level of hs-CRP and HbA1c were based on the 66th percentiles: hs-CRP ≥0.15 mg/dL and Hba1c ≥5.60%