TABLE 1.
Median (IQR) log CFU/mL and percentage of live cells in the planktonic model according to each group of treatment
| Microorganisma | Treatmenta | Median (IQRa) log CFU/mL | P valueb | Median (IQR) % live cells | P valueb |
|---|---|---|---|---|---|
| Overall | +C | 8.98 (6.40–9.20) | 92.7 (5.40–100) | ||
| TXA 50 mg/mL | 8.58 (5.30–9.20) | 0.011 | 90 (0.0–100) | 0.539 | |
| TXA 10 mg/mL | 7.69 (0.00–9.00) | <0.001 | 69.8 (0.0–100) | 0.031 | |
| MSSA | +C | 8.92 (8.48–9.11) | 91.7 (22.2–98.7) | ||
| TXA 50 mg/mL | 8.47 (8.00–8.60) | 0.002 | 79.7 (2.0–100) | 0.083 | |
| TXA 10 mg/mL | 8.35 (7.88–8.95) | <0.001 | 24.4 (0.0–76.6) | <0.001 | |
| MRSA | +C | 9.10 (9.00–9.15) | 72.1 (5.4–100) | ||
| TXA 50 mg/mL | 8.71 (8.70–8.86) | 0.004 | 19.2 (0.0–95.7) | 0.199 | |
| TXA 10 mg/mL | 8.56 (7.78–8.78) | 0.004 | 12.0 (1.4–71.4) | 0.054 | |
| S. epidermidis | +C | 9.11 (9.04–9.18) | 98.2 (71.7–99.1) | ||
| TXA 50 mg/mL | 9.00 (8.52–9.18) | 0.049 | 79.3 (1.2–99.4) | 0.024 | |
| TXA 10 mg/mL | 7.36 (3.18–9.00) | <0.001 | 76.1 (0.0–100) | 0.272 | |
| C. acnes | +C | 6.65 (6.40–7.20) | 89.5 (60.7–100) | ||
| TXA 50 mg/mL | 6.00 (5.30–7.08) | 0.044 | 100 (92.9–100) | <0.001 | |
| TXA 10 mg/mL | 1.65 (0.00–5.11) | <0.001 | 100 (92.3–100) | 0.004 |
a
IQR, interquartile range; +C, positive control; TXA, tranexamic acid; MSSA, methicillin-susceptible Staphylococcus aureus; MRSA, methicillin-resistant Staphylococcus aureus.
b
P values in bold represent statistical significance for the TXA reduction effect.