TABLE 5.

Frequency of immunosuppressive treatment and dose changes after introduction and discontinuation of isavuconazole^a

Immunosuppressive	On isavuconazole	Off isavuconazole
Tacrolimus	n = 47	n = 48
Initial dose adjustment	22 (46.8) decreased dose	17 (35.4) increased dose 2 (4.1) decreased dose
Adjustment in first 14 days	40 (85.1)	24 (50)
mTOR inhibitor  Sirolimus  Everolimus	n = 7 6 (85.7) 1 (14.3)	n = 5 4 (80) 1 (20)
Adjustment in first 14 days	6 (85.7) decreased dose	2 (40) increased dose

^aData are expressed as numbers (%) unless otherwise indicated.