TABLE 1.

MICs of WX-081 against different mycobacterial species^a

Clinical strains	MICs (ug/mL)
	WX-081	BDQ	INH	RFP	MFX	KM
13946: resistant to INH SM RFP EMB RBT PAS OFX	0.098	0.021	1.813	>40	0.220	0.788
14550: resistant to INH SM RFP EMB KM CPM AK 1321 PAS	0.170	0.051	2.251	>40	1.129	1.186
14822: resistant to INH SM RFP EMB KM RBT AK 1321 PAS	0.480	0.111	>40	>40	1.001	>40
14158: resistant to INH SM RFP EMB AK 1321 PAS OFX	0.111	0.030	>40	>40	2.329	>40
14441: resistant to INH RFP RBT AK CPM 1321 OFX LFX	0.465	0.214	>40	>40	2.122	>40
14470: resistant to INH SM RFP EMB KM RBT AK CPM 1321 PAS	0.966	0.468	>40	>40	4.633	0.437
13908: resistant to INH RFP EMB 1321 PAS OFX LFX	0.849	0.266	3.008	6.904	1.742	1.151
14282: resistant to INH SM RFP EMB RBT 1321 OFX LFX	0.113	0.053	2.347	>40	0.307	1.199
15321: resistant to INH RFP EMB AK ETO OFX RFT	0.109	0.028	1.037	>40	0.384	>40
14619: resistant to INH RFP KM CPM AK 1321 PAS	0.300	0.052	4.377	>40	1.098	1.195
16030: resistant to INH RFP RFT	0.057	0.017	2.448	>40	0.019	1.072
14862: resistant to INH SM RFP EMB 1321 CPM PAS	0.026	0.006	2.166	15.216	1.053	1.243
16825: resistant to INH RFP AK RFT	0.226	0.060	2.373	>40	0.501	>40
15833: resistant to INH RFP RFT	0.236	0.090	4.495	>40	0.066	2.302
14092: resistant to INH SM RFP	0.235	0.048	2.406	>40	0.605	1.199
Susceptible strain 14241	0.117	0.029	0.034	0.035	0.122	2.417
Susceptible strain 14242	0.219	0.031	0.028	0.066	0.037	1.146
Susceptible strain 14280	0.124	0.053	0.024	0.057	0.035	1.219
Susceptible strain 14286	0.152	0.043	0.030	<0.02	0.039	1.154
Susceptible strain 14480	0.120	0.037	<0.02	0.046	0.038	1.907
H37Rv	0.070	0.012	0.031	0.014	0.045	0.730

^aEthambutol, EMB; isoniazid, INH; rifampicin, RFP; rifapentine, RFT; rifabutin, RBT; ethionamide, ETO; streptomycin, SM; capreomycin, CPM; para aminosalicylic acid, PAS; protionamide, Th1321; levofloxacin, LFX; moxifloxacin, MFX; ofloxacin, OFX; kanamycin, KM; amikacin, AK; bedaquiline, BDQ.