TABLE 3.
Pooled week 8 fold change and fold change since previously recorded time point of CRP, IL-6, IP-10, and TNF-α among people with TB on therapyd
| Biomarker | Data for baseline to week 8 |
Data since previously recorded time point |
||||
|---|---|---|---|---|---|---|
| No. of studiesa | No. of participants | Avg fold change (% [95% CI]) | No. of Studies | No. of participantsb | Avg fold change (% [95% CI]) | |
| CRP | 5 | 275 | −76.1 (−89.4 to −62.9) | 7 | 447c | −53.9 (−70.2 to −37.5) |
| IL-6 | 4 | 522 | −24.7 (−50.7 to 1.3) | 5 | 558 | −31.0 (−59.5 to −2.5) |
| IP-10 | 4 | 154 | −38.2 (−61.3 to −15.0) | 9 | 430 | −36.2 (−49.0 to −23.4) |
| TNF-α | 4 | 497 | −10.3 (−24.7 to −4.2) | 6 | 517c | −17.7 (−31.3 to −4.0) |
a
Only includes studies that collected data at week 8 (Table S6 in the supplemental material).
b
At enrollment.
c
Number of participants in Zhu et al. (90) was not specified.
d
CRP, C-reactive protein; IL-6, interleukin-6; IP-10, interferon gamma-induced protein 10; TNF-α, tumor necrosis factor alpha; CI, confidence interval.