TABLE 1.

Recommended donor selection criteria based on presently published guidance and protocols^a

Characteristic	Consistently recommended	Occasionally recommended	Case-by-case basis	Recently recommended
Relationship to patient
Intimate, long-time partner (25, 26, 51, 52)	•
Unknown to patient (26, 53)		•
Inclusion criteria
Age > 18 (25, 26, 34, 52, 53)	•
Children with parental consent and child assent (25, 52)			•
Negative screening questionnaire similar to those given to potential blood donors (23, 25, 26, 34, 51–53)	•
Exclusion criteria
Risk factors for transmittable diseases (e.g., new sexual contact in last six mo, recent needle stick accident, recent transfusion, i.v. drug use, risk for variant Creutzfeldt-Jakob disease, sex for drugs or money, homosexuality, or tattoos) (23, 24, 26, 34, 53)	•
Travel to tropical area in last 3 mo (23, 25, 26, 34, 51, 53)	•
Known history of tropical infection (23)				•
Employment in clinical work (23, 34, 53)				•
Use of antibiotics in the 3 mo prior to donation (23, 25, 26, 34, 51–53)	•
Diarrhea (≥3 loose or watery stools per day for at least 2 consecutive days or ≥8 loose stools in 48 hours (23, 34, 51, 53)		•
Household contacts with active gastrointestinal infection (26)		•
Abnormal blood or stool test result suggestive of active/current disease (23, 25, 26, 34, 51–53)	•
Any gastrointestinal illness (inflammatory bowel disease, irritable bowel syndrome, gastrointestinal malignancies, or major gastrointestinal surgery) or complaints (23, 25, 26, 34, 51–53)	•
Family history of intestinal cancer or inflammatory bowel disease  (23, 34, 52)				•
Diet (51)			•
History of autoimmune or atopic illness or ongoing immune modulating therapy (23, 25, 26, 34, 51, 53)	•
History of chronic pain syndromes (fibromyalgia, chronic fatigue) or neurologic or neurodevelopmental disorders (25, 26, 34, 51, 53)	•
History of psychiatric conditions (25, 34)				•
Metabolic syndrome, obesity (BMI of >30), moderate to severe undernutrition (23, 25, 26, 34, 51, 53)	•
History of malignancy/receipt of chemotherapy (23, 25, 26, 34, 51, 53)	•

^aConsistently recommended, recommended in >4 guidance/protocols; occasionally recommended, recommended in some but not >4 guidance/protocols; case-by-case basis, case-by-case consideration of screening is suggested; recently recommended, recently recommended in response to reported safety concerns. i.v., intravenous; BMI, body mass index.