Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 2;9:794456. doi: 10.3389/fmed.2022.794456

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Gebetsberger, Schirmer, Wurzer and Streif.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The role of coagulation FVIII in bone health. Current knowledge tells us that several modes of action for FVIII impacting bone mineral density are feasible: either FVIII plays a role outside the coagulation system and directly interacts with main players of bone physiology, including the RANK/RANKL/OPG axis and/or the Wnt/β-catenin pathway, as well as pro-inflammatory cytokines, or the effect happens downstream of FVIII and e.g., the missing interaction with vWF or decreased thrombin production is causative. References for original publications and further reading are written in brackets.