Fig. 4. Dot map of drug screening on all three samples procured from patient CHORD002.

(A and B) Drugs that induce 15% cell death in at least two of the samples are visualized (51 total). The size of each circle represents the Z score, with larger ones indicating a higher Z score value. The color of each point represents the normalized cell viability %. The drugs are clustered using the Jaccard distance based on common protein targets. Samples are ordered by date of acquisition. Covariates included represent the type of tissue, anatomic location of each sample, and the number of lines of treatment the patient was exposed to before procurement of sample as well as FDA status at the time of publication.