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. 2022 Feb 16;8(7):eabm1418. doi: 10.1126/sciadv.abm1418

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Fig. 2. — (A) Physicochemical property characterization of iLAND before and after siRNA encapsulation, which includes the size, PDI, zeta potential, encapsulation efficiency (E.E.), and loading efficiency (L.E.). (B) TEM image of siRNA@iLAND. (C) TNS was used for pKa determination, and the pKa of iLAND was approximately 6.16. (D) Cell viabilities of siRNA@iLAND were evaluated by using HepG2 cells. n = 6. (E) Chemical stability of A1-D1-5 and (F) formulation stability of siRNA@iLAND. RT, room temperature. (G) Cellular uptake and (H) the MFI of siRNA@iLAND, comparison with siRNA@Lipo. (I) Subcellular localization of siRNA@iLAND or siRNA@Lipo2000. ns, not significant.