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. 2022 Feb 16;8(7):eabm1418. doi: 10.1126/sciadv.abm1418

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Fig. 4. — (A) Cellular uptake of Cy5-siRNA@iLAND in HepG2 cells at different transfection time points. (B) Intracellular fluorescence intensities of siRNA at different time points after transfection. (C) Colocalization between Cy5-siRNA and endosome or lysosome. The highest level occurred around 3 hours after transfection. (D) Influence of chloroquine and bafilomycin A1 on cellular entry and endosomal escape of siRNA@iLAND. (E and F) Colocalization analysis (E) and MFI of siRNA in cells (F) that recorded in (D). (G) Scheme of iLAND-mediated siRNA escape from endosome (or lysosome). siRNA was transfected at a final concentration of 50 nM. n = 6.