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. 2022 Feb 9;2022:4295208. doi: 10.1155/2022/4295208

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Copyright © 2022 Shiqi Gao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The sensitivity of different types of microglia to ferroptosis, and the effect of CEP on the expression of ALOX15 and GPx4 in hemin-induced BV2in vitro. (a, c) Representative images of iNOS and CD206 immunostaining in different polarization types of BV2 cells. (b, d) RSL3 decreased cell viability in M1- (b) and M2- (d) type microglia detected by CCK-8. ^∗p < 0.05 vs. control, n = 6 per group. (e–g) Representative Western blot bands and densitometric quantification showed the protein level of ALOX15 and HO-1 in different polarization types of microglia. ^∗p < 0.05 vs. M0 group, ^#p < 0.05 vs. M1 group, n = 6 per group. (h–j) Representative Western blot bands and densitometric quantification showed the effect of CEP on GPx4 and ALOX15 expression in hemin-treated M2-type microglia. ^∗p < 0.05 vs. control, ^#p < 0.05 vs. hemin, n = 6 per group.