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. 2022 Feb 9;602(7897):510–517. doi: 10.1038/s41586-022-04398-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Pan-cancer distribution of clustered substitutions subclassified into DBSs, MBSs, omikli, kataegis and other clustered mutations. Top, each black dot represents a single cancer genome. Red bars reflect the median clustered TMB (mutations (mut) per Mb) for cancer types. Middle, the clustered TMB normalized to the genome-wide TMB reflecting the contribution of clustered mutations to the overall TMB of a given sample. Red bars reflect the median contribution for cancer types. Bottom, the proportion of each subclass of clustered events for a given cancer type with the total number of samples having at least a single clustered event over the total number of samples within a given cancer cohort. b, Pan-cancer distribution of clustered small indels. The top and middle panels have the same information as a. Bottom, the proportion of each cluster type of indel for a given cancer type with the total number of samples having at least a single clustered indel over the total number of samples within a given cancer cohort. All 2,583 whole-genome-sequenced samples from PCAWG are included in the analysis; however, cancers with fewer than 10 samples were removed from the main figure and included in Extended Data Fig. 1d. For definitions of abbreviations for cancer types used in the figures, see 'Cancer-type abbreviations' in Methods.