Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 23;602(7897):487–495. doi: 10.1038/s41586-021-04352-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 6 — a, Full kinase activity analysis of indicated contrasts with z-score>2. Kinases were separated using k-means clustering, which naturally reveals groups depicting kinases downregulated for the entire time course (“Down”), downregulated early and upregulated late (“Down-Up”), upregulated early and downregulated late (“Up-Down”), or upregulated or constant throughout the time course (“Up”). Panel on the right depicts the average Z-score for each distinct cluster per time point, collapsing across Alpha/VIC and Alpha/IC19 comparisons. b, Correlation between the calculated kinase activity Z-score and protein (left) or RNA (right) abundance log2FC for kinases with estimated activities in our dataset. Vertical dashed lines indicate kinase activity of ±2, horizontal dashed lines indicate protein log2FC of ±1. Colours represent comparisons between viruses and time points as indicated. c, Detected substrates known to be phosphorylated by TBK1. Log2FC of each phosphorylation site is depicted. Those not detected are indicated in grey. d, Transcription factor (TF) activities were estimated from the RNA-seq dataset using known TF-target gene interactions. Included are TFs with a NES>2.5. TF are clustered using ward hierarchical clustering based on similar activity patterns across time.