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Comparison of outputs from tier 2, tier 3, and conventional hazard assessments for ECI
| Tier 2—in vitro | Tier 3—targeted in vivo | Conventional studies | |
|---|---|---|---|
| STOT-RE category | 1 | 1 | 1 |
| Reproductive Tox category | 1 | 2 | 2 |
| Carcinogenicity category | 1 | 2 | 2 |
| DNEL | 0.006 mg/kg | 0.04 mg/kg | 0.024 mg/kg |
| Number of animals used | 0 | 100 | 2200 |
