Table 2.
Treatment, time course, and outcomes in patients with anterior and posterior circulation occlusion
| Characteristics | Total | Anterior circulation occlusion | Posterior circulation occlusion | p value |
|---|---|---|---|---|
| Intravenous rt-PA (%) | 180 (51.0) | 162 (51.6) | 18 (46.2) | 0.522 |
| First-pass devices | ||||
| Stent retriever (%) | 101 (28.6) | 90 (28.7) | 11 (28.2) | 0.952 |
| Aspiration catheter (%) | 123 (34.8) | 110 (35.0) | 13 (33.3) | 0.834 |
| Combined approach (%) | 103 (29.2) | 93 (29.6) | 10 (25.6) | 0.606 |
| Other devices (%) | 26 (7.4) | 21 (6.7) | 5 (12.8) | 0.187 |
| PTA (%) | 46 (13.0) | 41 (13.1) | 5 (12.8) | 0.967 |
| Stent placement (%) | 19 (5.4) | 17 (5.4) | 2 (5.1) | 1.000 |
| Medical therapy other than rt-PA (%) | 35 (9.9) | 34 10.8) | 1 (2.6) | 0.152 |
| Time course | ||||
| Onset-to-door time, median (IQR), min | 112.5 (58.8–240.5) | 112 (60–241) | 117 (53–314) | 0.888 |
| Door-to-picture time, median (IQR), min | 17 (12–25) | 17 (12–24) | 24 (16–36) | 0.005* |
| Door-to-needle time, median (IQR), min | 74 (61–89) | 72 (61–85) | 93 (83–123) | < 0.001* |
| Door-to-puncture time, median (IQR), min | 69 (46–102) | 65 (45–99) | 99 (51–121) | 0.018* |
| Picture to puncture time, median (IQR), min | 56.5 (36–80.3) | 52 (35–76.5) | 77 (60–96) | 0.001* |
| Puncture-to-reperfusion time, median (IQR), min | 49 (31–74) | 48 (31–74) | 52 (37–77) | 0.384 |
| Door-to-reperfusion time, median (IQR), min | 127 (93–165) | 125 (90–156) | 163 (121–203) | 0.004* |
| Onset-to-reperfusion time, median (IQR), min | 270 (195–376) | 267 (191–370) | 295 (231–442) | 0.079 |
| TICI 2B-3 reperfusion (%) | 287 (81.3) | 257 (81.8) | 30 (76.9) | 0.457 |
| TICI 3 reperfusion (%) | 160 (45.3) | 141 (44.9) | 19 (48.7) | 0.652 |
| First-pass TICI 2B-3 reperfusion (%) | 157 (44.4) | 137 (43.6) | 20 (51.3) | 0.364 |
| Number of passes†, median (IQR) | 3 (2–4) | 3 (2–4) | 2 (2–3) | 0.036* |
| Symptomatic complication | ||||
| Ischemic complication (%) | 2 (0.6) | 2 (0.6) | 0 (0) | 1.000 |
| Hemorrhagic complication (%) | 20 (5.7) | 19 (6.1) | 1 (2.6) | 0.711 |
| Puncture related complication (%) | 8 (2.3) | 7 (2.2) | 1 (2.6) | 1.000 |
| Hospitalization period (IQR), day | 29 (18–41) | 29.5 (18.3–41) | 27 (12–39) | 0.226 |
| mRS at discharge | 3 (2–5) | 3 (2–5) | 4 (2–5) | 0.325 |
| mRS ≤ 2 at discharge (%) | 118 (33.4) | 106 (33.8) | 12 (30.8) | 0.709 |
| Mortality (%) | 30 (8.5) | 22 (7.0) | 8 (20.5) | 0.010* |
*p < 0.05. †In cases that were not achieved successful reperfusion in the first pass
rt-PA recombinant tissue-type plasminogen activator, PTA percutaneous transluminal angioplasty, IQR interquartile range, TICI Thrombolysis in Cerebral Ischemia