. 2022 Feb 3;13:840797. doi: 10.3389/fgene.2022.840797

TABLE 1.

Characteristics of all studies included in the systematic review and meta-analysis.

Studies including more than one ethnicity
Study	Author	Year	Country	Source	Mean age	Sex, %	FH criteria		Sample size, N	Total FH cases, N	Total prevalence, %	Ethnicities	Prevalence and ethnicity %
NHANES de Ferranti et al. (2016)	De Ferranti et al.	2016	United States	GP	46.8 years	F: 51.4	DLCN		36,949	148	0.4	Black, Latino, white, mixed/other	Black: 0.46 Latino: 0.37 white: 0.40 mix./oth.: 0.28
NHANES de Ferranti et al. (2016)	De Ferranti et al.	2016	United States	GP	46.8 years	M: 48.6	DLCN		36,949	148	0.4	Black, Latino, white, mixed/other	Black: 0.46 Latino: 0.37 white: 0.40 mix./oth.: 0.28
ELSA-Brasil Harada et al. (2018)	Harada et al.	2018	Brasil	GP	HeFH: 55 years	F: 54	DLCN		14,460	55	0.38	16% black, 53% white, 29% mixed	Black: 0.67, white: 0.25, brown: 0.48
ELSA-Brasil Harada et al. (2018)	Harada et al.	2018	Brasil	GP	HeFH: 55 years	M: 46	DLCN		14,460	55	0.38	16% black, 53% white, 29% mixed	Black: 0.67, white: 0.25, brown: 0.48
The Cape Town Experience Firth and Marais (2008)	Firth et al.	2008	South Africa (Cape Town)	Patients from a lipid clinic	HeFH: 44 years	F: 53	Clinical equal to modified DLCN		4,494	1,029	23	Black, white, Asian colored	Black: 4.90, white: 32.2, Asian: 19.8 mix./oth.: 17.2
The Cape Town Experience Firth and Marais (2008)	Firth et al.	2008	South Africa (Cape Town)	Patients from a lipid clinic	HeFH: 44 years	M: 47	Clinical equal to modified DLCN		4,494	1,029	23	Black, white, Asian colored	Black: 4.90, white: 32.2, Asian: 19.8 mix./oth.: 17.2
MyHEBAT FH Study, Malaysia Chua et al. (2021)	Chua et al.	2021	Malaysia	GP	53.7 years	F: 62.6	DLCN		5,135	55	1.1	Malay, Chinese, Indian, Others	Asian: 1.2%, Others: 0.4%
MyHEBAT FH Study, Malaysia Chua et al. (2021)	Chua et al.	2021	Malaysia	GP	53.7 years	M: 38.4	DLCN		5,135	55	1.1	Malay, Chinese, Indian, Others	Asian: 1.2%, Others: 0.4%
The Young MI Registry Singh et al. (2019)	Singh et al.	2019	United States	Young adults with MI	45 years	F: 19.1	DLCN		1,996	180	9	Black, hispanic/Latino, white, Asian, mixed/other	Black: 9.8, Latino: 14.0.98 white: 8.79, Asian: 4.3 mix./oth. : 8.1
The Young MI Registry Singh et al. (2019)	Singh et al.	2019	United States	Young adults with MI	45 years	M: 80.9	DLCN		1,996	180	9	Black, hispanic/Latino, white, Asian, mixed/other
Studies including one ethnicity
Copenhagen City Heart Study, DK Tybjaerg-Hansen et al. (2005)	Tybjærg-Hansen et al.	2005	Denmark	GP	53 years	F: 55		DLCN	9,255	15	0.17	100% white	White: 0.17
	Tybjærg-Hansen et al.	2005	Denmark	GP	53 years	M: 45		DLCN	9,255	15	0.17	100% white	White: 0.17
Copenhagen General Population Study Benn et al. (2016)	Benn et al.	2016	Denmark	GP	NA	F: 55		Genetic	98,098	450	0.46	100% white	White: 0.46
Copenhagen General Population Study Benn et al. (2016)	Benn et al.	2016	Denmark	GP	NA	M: 45		Genetic	98,098	450	0.46	100% white	White: 0.46
LIFE Child Health Cohort, GE Dathan-Stumpf et al. (2016)	Dathna-Stumpf et al.	2016	Germany	GP	0–16 years	F:52.3		Clinical HeFH	2,571	6	0.23	Caucasian	White: 0.23
LIFE Child Health Cohort, GE Dathan-Stumpf et al. (2016)	Dathna-Stumpf et al.	2016	Germany	GP	0–16 years	M: 47.7		Clinical HeFH	2,571	6	0.23	Caucasian	White: 0.23
MyCode cohort, US Abul-Husn et al. (2016)	Abul-Husn et al.	2016	United States	GP	61 years	F: 59.2, M: 40.8		Genetic	43,979	172	0.39	98.4% Caucasian	White: 0.39
Allina Health ambulatory Facility, US Knickelbine et al. (2016)	Knickelbine et al.	2016	United States	GP	FH:53 No FH: 54.1 years	F: 55		Clinical National Lipid Assoc. Guidelines	391,166	841	0.21	90% white	White: 0.21
	Knickelbine et al.	2016	United States	GP	FH:53 No FH: 54.1 years	M: 45		Clinical National Lipid Assoc. Guidelines	391,166	841	0.21	90% white	White: 0.21
Jiangsu Nutrition Study Wijesekera et al. (2014)	Shi et al.	2014	China	GP	57 years	NA		DLCN	9,324	26	0.28	Asian	Asian: 0.28
Kumamoto Health Care, Japan Ohta et al. (2002)	Ohta et al.	2002	Japan	GP	18 months	NA		Clinical HeFH family study	56,181 adj. size: 47,877	91	0.19	Asian	Asian: 0.19
Korean Meta. Syndrome Mortality Study Jung et al. (2018)	Jung et al.	2018	Korea	GP	44.3 years	F: 42.6		MEDPED	502,966	540	0.11	Asian	Asian: 0.19
Korean Meta. Syndrome Mortality Study Jung et al. (2018)	Jung et al.	2018	Korea	GP	44.3 years	M: 57.4		MEDPED	502,966	540	0.11	Asian	Asian: 0.19

GP, general population; F, female; M, male; HeFH, heterozygous familial hypercholesterolemia; DLCN, Dutch Lipid Clinic Network Criteria; MEDPED, Make Early Diagnosis Prevent Early Death; NA, not available.