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. 2022 Feb 3;8:775194. doi: 10.3389/fsurg.2021.775194

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Copyright © 2022 Xiao, Yang, Wang, Zhao, Deng, Ji, Zou, Qian, Liu, Xiao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between CD44 and anti-PD-1 immunotherapy in recurrent GBM. (A) Principal component analysis of responder (R) and nonresponder (NR) recurrent GBM treated with anti-PD-1 immunotherapy based on RNA-seq data. (B) NR subgroup is enriched in REACTOME PD-1 signaling pathway compared to R subgroup. (C) Heatmap of CD44 and its directly interacted inhibitory immunomodulators expression between R and NR recurrent GBM subgroups. NR group was compared to R group, and the matching log2FC and p-value of each gene were shown in the right column.