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. 2022 Feb 3;8:775194. doi: 10.3389/fsurg.2021.775194

Figure 5.

Figure 5

CD44 is closely correlated with immune microenvironment in glioma. (A) Heatmap of immune score and stromal score in TCGA and CGGA gliomas. The higher CD44 expression level the glioma has, the higher immune score and stromal score it is, which reflects glioma with elevated CD44 expression has more infiltrating immune cells. (B) Component types of 22 human immune cells infiltrated into glioma were analyzed by CIBERSORTx in TCGA and CGGA glioma datasets. Glioma with high CD44 expression has more infiltrating M2-type macrophages.