. 2022 Feb 3;13:842535. doi: 10.3389/fimmu.2022.842535

Table 1.

Two categories of myeloid-derived suppressor cells and functions.

Type of MDSC	Markers		Immunosuppression mediators and mechanisms
Type of MDSC	Murine	Human	Immunosuppression mediators and mechanisms
PMN-MDSCs	CD11b⁺Ly6G⁺Ly6C^low	CD11b⁺CD14^-CD15⁺HLADR^-	Suppressive immune responses, ROS, ARG1, CD33, and CD66b
	CD11b⁺GR-1^high	CD11b⁺CD14^-CD66b⁺
		LOX-1⁺
M-MDSC	CD11b⁺Ly6G^-Ly6C^high	CD11b⁺CD14⁺CD15^-HLADR^low/-	Suppressive T cell responses, NO, iNOS, ARG1, pSTAT3, S100A8/9, IL-4R, TGF-1β, HLA-DR, and IRF8
M-MDSC	CD11b⁺GR-1^low