Table 2.

Overview of SCOPE-CLI Inclusion and Exclusion Criteria.

Inclusion Criteria	Exclusion Criteria
1.Age ≥ 18 years	1.Acute limb ischemia
2.ABI and TBI performed within the last 6 months (if patient undergoes revascularization, patient can be enrolled if a pre-procedural ABI/TBI is available)	2.Currently a prisoner
3.Patient presents with current (within 30 days) Rutherford Class 4, 5, or 6 as defined as any of the following: -Rutherford Classification 4 or ischemic rest pain or resting ankle pressure < 50 mmHg, flat or barely pulsatile ankle or metatarsal PVR or toe pressure < 40 mmHg -Rutherford Classification 5 or minor tissue loss; non-healing ulcer, focal gangrene with diffuse pedal ischemia or resting ankle pressure < 50 mmHg, or flat or barely pulsatile ankle or metatarsal PVR, or toe pressure < 40 mmHg -Rutherford Classification 6 or major tissue loss: extending above transmetatarsal level, functional foot no longer salvageable or resting ankle pressure < 50 mmHg, or flat or barely pulsatile ankle or metatarsal PVR, or toe pressure < 40 mmHg -CLI related ICD 10 code (reason for admission or indication for procedure) - Documentation of any of the following diagnostic evidence: i. SPP < 50 mmHg ii. TCPO2 < 50 mmHg iii. Angiographic evidence no straight line to foot or>70% stenosis in all 3 lower extremity arteries (AT, PT, peroneal) iv. ABI* ≤ 0.90 v. Non-compressible ABI ≥ 1.40 AND TBI ≤ 0.70 vi. TBI* ≤ 0.70	3.Unable to provide written informed consent
4.English or Spanish speaking

(*) These diagnostic testing results must be present to enter the study.

Abbreviations: ABI, Ankle Brachial Index; AT, anterior tibial; ICD, International Classification of Diseases; PT, posterior tibial, PVR, Pulse Volume Recording; SPP, skin perfusion pressure; TBI, toe brachial index; TCPO2, transcutaneous oximetry