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Effects of E64 in db/db mice. db/db mice (n = 6/group) were i.p. administered with E64 at a dose of 5 or 10 mg/kg daily (referred to as E64-5 and E64-10, respectively) for three weeks. (A) Fasting blood glucose. (B) Plasma insulin. (C) HOMA-IR. (D) ITT. (E) ITT-AUC. (F) Urine output. (G) Water intake. (H) Food intake. (I) Body weight. Data are presented as the mean ± SEM. **P < 0.01 and ***P < 0.001, compared to the control.
