Fig. 4.

E64 regulates multiple targets associated with insulin sensitivity. db/db mice (n = 6/group) were i.p. administered with E64 at a dose of 5 or 10 mg/kg daily (referred to as E64-5 and E64-10, respectively) for three weeks. (A) Hepatic SELENOP and TXNIP proteins. (B) Hepatic GPx activity. (C) Hepatic Trx activity. (D) Renal SELENOP and TXNIP proteins. (E) Renal Trx activity. (F) Serum SELENOP. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001, compared to the control.