TABLE 1.

The characteristics of the cohort observational studies included in the systematic review.

Study	N	Ethnicity	Mean age ± SD (range) in years	Gender, % Male	Antipsychotics	Mean dose ± SD (range)	Duration of treatment	Diagnosis	CYP2D6 alleles genotyped
Lu et al., 2021	76	Not reported (China)	45 (35–54)	100%	Risperidone	5 (2–6) mg/day	8 weeks	Schizophrenia	*2, *10, and *65
Jallaq et al., 2021	277	European descents (83.3%), African–Caribbean (10.8%)	14.3 ± 2.4 (6.0–19.6)	34.3%	Aripiprazole	Maximum dose 30 mg/day	Not reported	Mood disorder (e.g. bipolar, major depressive disorder)	*2A, *3, *4, *5, *6, *7, *8, *9, *10, *11, *14, *15, *17, *18, *19, *20, *40, *41, *42, and *44.
Nussbaum et al., 2014	81	Not reported (Romania)	15.7 (9–20)	46%	Risperidone, Aripiprazole, Olanzapine	Not reported	At least 18 months	Schizophrenia, bipolar disorders	*4
Correia et al., 2010	45	European descents (97.8%)	8.7 ± 4.30 (3–21)	75.6%	Risperidone	1.3 ± 0.7 (0.5–3) mg/day	At least 12 months	Autism	*3, *4, *5, *6 and gene duplication.
Lane et al., 2006	123	Asian (Hans Chinese)	34.0 ± 9.7	55.3%	Risperidone	4.0 ± 1.4 mg/day (at end point – day 42)	42 days	Schizophrenia with acute exacerbations	*10 (188-C/T)
Ellingrod et al., 2002	11	European descents	35.6 ± 5.5	100%	Olanzapine	14.3 ± 3.4 mg/day	Mean 13.8± 13.6 months	Schizophrenia	*3 and *4