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. 2022 Feb 3;13:710099. doi: 10.3389/fphar.2022.710099

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Copyright © 2022 Duan, Zhou, Feng, Zhu, Cai, Wang, Zhu, Li, Yuan, Liu, Sun, Yang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Distribution of LZD initial trough concentration in the LIT group and non-LIT group. Compared with the non-LIT group, trough concentration was significantly higher in the LIT group [11.49 (6.86, 15.13) vs. 5.51 (2.80, 11.61), *p = 0.027]. (B) Distribution of LZD AUC_24h in the LIT group and non-LIT group.