Table 2.
Binary logistic regression analysis of factors associated with high (≥26) Oncotype DX® recurrence score.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | |
| T stage | ||||
| 1 | Ref | Ref | ||
| 2 or 3 | 3.680 (1.345–10.067) | 0.011 | 4.262 (1.161–15.646) | 0.029 |
| N stage | ||||
| Negative | Ref | |||
| Positive | 0.261 (0.058–1.177) | 0.08 | ||
| Estrogen receptora | ||||
| High | Ref | |||
| Low | 1.090 (0.222–5.352) | 0.915 | ||
| Progesterone receptor | ||||
| Positive | Ref | Ref | ||
| Negative | 4.659 (1.643–13.212) | 0.004 | 9.214 (2.275–37.311) | 0.002 |
| Histologic grade | ||||
| 1 or 2 | Ref | - | - | |
| 3 | 6.171 (2.088–18.239) | 0.001 | - | - |
| Nuclear grade | ||||
| 1 or 2 | Ref | |||
| 3 | 2.432 (0.874–6.761) | 0.089 | ||
| Ki-67 | ||||
| ≤20 | Ref | - | - | |
| >20 | 10.781 (2.742–42.385) | 0.001 | - | - |
| LVIb | ||||
| Negative | Ref | |||
| Positive | 1.112 (0.399–3.102) | 0.839 | ||
| TP53 mutation | ||||
| Negative | Ref | Ref | ||
| Positive | 22.600 (6.986–73.116) | <0.001 | 21.632 (5.877–79.627) | <0.001 |
aHigh, Allred score 5–8; Low, Allred score 2–4.
bLymphovascular invasion.