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. 2022 Feb 16;12:2574. doi: 10.1038/s41598-022-06580-2

Table 3.

Sensitivity analyses—results from eleven multivariable logistic regression models assessing the associations of peyote use (independent variable) to DSM-IV criteria for cocaine use disorder (CUD) (lifetime use of all other substances and all demographic factors included as covariates) + criteria frequency.

Cocaine use disorder criteria Frequency
(unweighted N)1
aOR (95% CI)1
Dependence criteria
1. Significant Time Spent Getting/Using 982 0.44* (0.22, 0.90)
2. Use More Than Intended 445 0.32* (0.13, 0.82)
3. Decreased Effects/Need More for Same Effect 1,041 0.47* (0.23, 0.95)
4. Unable to Cut Back 310 0.26* (0.09, 0.78)
5. Emotional/Physical Health Problems 561 0.53 (0.24, 1.16)
6. Fewer Important Activities 580 0.55 (0.25, 1.21)
7. Feeling Blue & 2 + Withdrawal Symptoms 434 0.65 (0.30, 1.42)
Abuse criteria
8. Significant Work/Home/School Problems 505 0.42* (0.18, 0.96)
9. Use in Physically Hazardous Situations 518 0.36** (0.18, 0.69)
10. Legal Trouble 223 0.47 (0.14, 1.53)
11. Relational Issues 377 0.32* (0.11, 0.90)

Significant values that indicate lowered odds of CUD criteria are in bold.

1*p < 0.05; **p < 0.01; ***p < 0.001; aOR = adjusted odds ratio; CI = confidence interval.